Transdermal Drug Delivery Academic Article uri icon

abstract

  • In spite of major research and development efforts in transdermal systems and the many advantages of the transdermal route, impermeability of the human skin is still a major problem that limits the usefulness of the transdermal approach. It is well accepted that the stratum corneum is the major rate-limiting barrier to molecular diffusion through the mammalian epidermis.” Because most drugs do not permeate the skin in therapeutic amounts, chemical and physical ap-proaches have been examined to lower the stratum …

publication date

  • November 30, 1993