- Brief cognitive-behavioral intervention (CBI) was conducted in the emergency room (ER). The current literature on biomedical and psychological risk factors of migraine is reviewed briefly including studies demonstrating the effectiveness of CBI with such patients. The case study portrays CBI that assists a patient suffering from severe migraine attack. We cautiously proposed that CBI can provide patients with a sense of control and may offer empowerment for the personnel in the ER. An integrative approach to health care is suggested when assessing patients with migraine.