T-Lymphocyte Activation: The Role of Protein Kinase C and the Bifurcating Inositol Phospholipid Signal Transduction Pathway Academic Article uri icon

abstract

  • T lymphocytes can be activated by interaction between a wide range of agonists and their respective cell surface receptors. Preceding activation, T cells are at Go, the resting stage of the cell cycle. After interaction with antigen or other ligands, such as mitogenic plant lectins or antibodies directed against various cell surface determinants, they undergo sequential differentiation steps that induce their entry into the d phase, rendering them responsive to additional signals which enable completion of the mitotic cycle. The first activation signal is provided by interaction between the antigen-specific receptor on T cells (TR) and nominal antigen associated with a membrane-bound major histocompatibility complex molecule. The monokine interleukin 1 seems to play a role in this event. As a result of this signal, ceil surface receptors for interleukin 2 (IL2) appear. Transition of T cells from Gi into the S …

publication date

  • January 1, 1987