Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression Academic Article uri icon


  • Abstract Acetyl-L-carnitine (ALCAR) contains carnitine and acetyl moieties, both of which have neurobiological properties. Carnitine is important in the beta-oxidation of fatty acids and the acetyl moiety can be used to maintain acetyl-CoA levels. Other reported neurobiological effects of ALCAR include modulation of:(1) brain energy and phospholipid metabolism;(2) cellular macromolecules, including neurotrophic factors and neurohormones;(3) synaptic morphology; and (4) synaptic transmission of multiple …

publication date

  • November 1, 2000