N, N-Dichlorourethane-A Selective Chlorination Reagent; Synthesis of Corticoids Academic Article uri icon

abstract

  • Introduction of a double bond between C‐9 and C‐11 of the steroid skeleton can be accomplished by (i) chlorination of the saturated steroid with N, N‐dichlorourethane (EtOCONCl2) followed by (ii) dehydrochlorination with AgClO4. The products, e.g.(1), can easily be functionalized at C‐11. (Figure Presented.)

publication date

  • April 1, 1978