Polarity-dependent effects of trans-cranial direct current stimulation (tDCS) in cerebellar learning depends on the state of neuronal network Academic Article uri icon

abstract

  • Polarity-dependent modulation of network activity makes transcranial direct current stimulation (tDCS) increasingly popular as a promising possibility for non-invasive therapeutic interventions, in a wide range of neurological and psychiatric disorders. However, a thorough understanding of the neuronal mechanisms through which tDCS acts is needed to understand its clinical potential, as well as to maximize effects. As a step towards building such an understanding, we explored (i) how mutations in cerebellar circuitry aff5ct the behavioral efficacy of tDCS and (ii) how neural activity reflects tDCS efficacy in both normal and mutated cerebellum. We have focused specifically on efficacy of tDCS in modulating gain-down vestibule-occular reflex (VOR) adaptation, and compared the effects of tDCS on Parallel fiber (PF) and Purkinje cell (PC) long term potentiation (LTP) …

publication date

  • January 3, 2014