Loop 8 Plays a Role in Controlling S. Cerevisiae Kinesin-5 Cin8 Motility and Function Academic Article uri icon


  • Kinesin-5 proteins are microtubule associated motors, which are highly conserved from yeast to human cells. They share high homology in their catalytic motor domain sequence, fulfill similar essential mitotic roles in spindle assembly and anaphase B spindle elongation and, until recently (Roostalu et al., Science, 2011), were all thought to move towards plus ends of microtubules. Mechanisms that regulate Kinesin-5 function, specifically during anaphase B, are not well understood.

publication date

  • January 1, 2012