Serum lipid profiles during pregnancy based on 35,000 lipidograms Academic Article uri icon

abstract

  • AMIT MAYER, LENA NOVACK, BORIS GOGERMAN, MAXIMUS MAISLOS, ARNON WIZNITZER, Soroka University Medical Center, Omer, Israel, Ben Gurion University of the Negev Faculty of Helth sciences, Epidemiology, Beer-Sheva, Israel, Soroka University Medical Center, Faculty of Health Sciences, BenGurion University of the Negev, Beer-Sheva, Israel, Intensive Care Unit, Beer-Sheva, Israel, Soroka University Medical Center, Faculty of Health Sciences, BenGurion University of the Negev, Beer-Sheva, Israel, Head, Atherosclerosis and Metabolism Unit, Beer-Sheva, Israel, Soroka University Medical Center, Beer-Sheva, Israel OBJECTIVE: To describe serum lipid profile among women before, during and after pregnancy and to measure the association between hyperlipidemia and obstetrical outcomes. STUDY DESIGN: Two databases were used. One contains all deliveries at Soroka Medical Center and the other, the Computerized Community Cholesterol Control System (4C), initially aimed for secondary prevention in coronary heart disease patients. The study population includes 14,977 women who were recorded in the 4C database, delivered during the time period of 1.1.2001-1.5.2005 and had a valid lipidogram (n=35,125). After excluding mismatches between the two databases 32,494 lipidograms (14,977 women) were included. In the current study we included 9,343 lipidograms that were obtained during 9 months of pregnancy and 2 months postpartum. Each lipidogram was related to the nearest pregnancy. Association between high lipidogram levels (mean C2 SD) and obstetrical outcome was investigated. RESULTS: The results of Total Cholesterol, Triglyceride, Low Density Lipoprotein and High Density Lipoprotein are described in the following curves, revealing a significant increase of these measures close to the date of delivery. Triglycerides above 327mg%, total cholesterol above 299 mg% and LDL above 180mg% were associated with adverse obstetrical outcome including preeclampsia, GDM and preterm delivery. Only hypertriglyceridemia was associated with increased rate of macrosomia.

publication date

  • January 1, 2006