Complexity and algorithms for copy-number evolution problems Academic Article uri icon

abstract

  • Background Cancer is an evolutionary process characterized by the accumulation of somatic mutations in a population of cells that form a tumor. One frequent type of mutations is copy number aberrations, which alter the number of copies of genomic regions. The number of copies of each position along a chromosome constitutes the chromosome‚Äôs copy-number profile. Understanding how such profiles evolve in cancer can assist in both diagnosis and prognosis.

publication date

  • January 1, 2017