- Iron deficiency is the most common cause of anemia and the most common nutritional deficiency. Iron (Fe) can be administrated orally, intramuscularly , and intravenously (IV). Intramuscular injection is very painful and can induce allergic reaction as well as regional lymphadenopathy. Not much experience with IV administration in children is available. Here we describe a group of 18 children between the age of 21 mouths and 13 years that were treated with IV -Fetherapy. Level of hemoglobin (Hg) prior to treatment were between 5g%-8.1g% (mean 6.9 ), level of ferritin were low in all patients (mean 1.5ng/ml normal range starting from26ng/ml ) . The reason for IV Fe therapy instead of oral administration in 6 patients was their non compliance , malabsorption was observed in 7 patients, Crhon disease in 1 patient .short gut syndrome in 1 patient, chronic autoimmune disease in 1 patient and kidney failure in 2 patients patient. All patient received Fe as iron -sucrose complex (Venofer ,Vifor ,CH) at dose of 50-100mg over 60-90 minutes daily for 4-7 days. A test dose of lOmg was given prior to each therapeutic dose. Sever side effect were observed in only 1 patient who vomited and was reduced blood pressure (probably due to fast administration) subsequently he was remove from the series. None of the other developed any serious side effect. 1 patient with exteravastion of the drug developed painless coloration at the site oh injection for 1 day which subsequently disappeared. One week post o treatment Hg levels increased between 0.6g%-3.5g%(mean l/9g%). Hg level after 6 months were 12.2g% (range 11.8-13.2) Ferritin level remaind low at 15ng/ml In conclusion IV administration of Fe in children is easily performed with relativly minor side effects leading to good clinical results.