Enhanced membrane pore formation by multimeric/oligomeric antimicrobial peptides. Academic Article uri icon

abstract

  • The pore-forming antibacterial peptide magainin 2 was made divalent, tetravalent, and octavalent via a copper (I)-mediated 1− 3 dipolar cycloaddition reaction (“click” chemistry). This series of pore-forming compounds was tested in vitro for their ability to form pores in large unilamillar vesicles (LUVs). A large increase in the pore-forming capability was especially observed with the tetravalent and octavalent magainin compounds in the LUVs consisting of DOPC, and the octavalent magainin compound showed a marked increase with the DOPC/DOPG LUVs. Activity was observed in the low nanomolar range for these compounds.

publication date

  • January 1, 2007