Time-dependent sensitization: the odyssey of a scientific heresy from the laboratory to the door of the clinic Academic Article uri icon


  • Abstract This review provides both a biological and clinical perspective on Time-Dependent Sensitization (TDS), an ancient amplified memory response to threat manifest in the ability of both drugs and nondrug stressors to induce neuronal and behavioral effects which strengthen entirely as a function of the passage of time following even a single or acute exposure. Evidence is presented to show that TDS may be involved in the development of a spectrum of diseases and how drug regimens based on the principles of TDS could …

publication date

  • January 1, 2000