Nupharidines Enriched Leaf Extract Of Nuphar Lutea Reduces Experimental Melanoma Metastasis And Modulates Erk And Nf-? B Pathways. Academic Article uri icon

abstract

  • Abstract Nuphar lutea L. SM., leaf and rhizome extracts (NUP), contain nupharidines as active ingredients. Nupharidines belong to the sesquiterpene lactones class of a naturally occurring plant terpenoids. This family of compounds has gained considerable interest for treating infection, inflammation and cancer. NF-? B is a central, downstream regulator of inflammation, cell proliferation and apoptosis. In our previous work we demonstrated strong inhibition of NF-? B activity and induction of apoptosis by NUP. In addition, NUP exhibited antiinflammatory properties and partial protection from LPS-induced septic shock by modulating ERK pathway and cytokine secretion in macrophages. In the present study, we examined the effect of NUP in a B16 melanoma experimental murine lung metastasis model and its ability to affect the ERK and NF-? B pathways in variety of cell lines. We showed …

publication date

  • December 2, 2017