Treatment of acute lung injury attributed to leptospirosis Academic Article uri icon


  • SIR—We read with interest the report of Marotto et al.[1] on the features and outcome of acute lung injury in leptospirosis. The severity of illness attributed to pulmonary hemorrhage due to Leptospira interrogans infection and the resulting mortality rate of 55% presented in their report are impressive. A significant portion of these patients also suffered from acute renal failure and shock, which were also independent risk factors for patient mortality. It is worth knowing whether the authors had used adjunctive supportive measures while caring for their patients, such as nitric oxide inhalation (iNO) or hemofiltration. We have recently published a report of leptospirosis complicated by massive pulmonary hemorrhage and acute renal failure that was unresponsive to conventional medical treatment [2]. The institution of iNO and hemofiltration resulted in prompt clinical improvement of both the …

publication date

  • January 1, 2000