Alzheimer Aβ amyloid tubular fibrils: Insight into polymorphism Academic Article uri icon

abstract

  • Abstract Elucidating the structure of Aβ 40/Aβ 42 fibrils is of interest in Alzheimer's disease research because it is required for designing therapeutics that target fibril formation at an early stage of the disease. Based on the cryoEM measurements and on ssNMR data, we probe various amyloid fibril organizations. Our study demonstrates that the two-fold symmetry tubular Aβ 42 fibril model with the C-termini facing the external surface of the fibril has a cavity, while model with the C-termini facing the internal surface of the fibril shrinks …

publication date

  • April 1, 2011