Neonatal sepsis caused by Streptococcus pyogenes : Resurgence of an old etiology? Academic Article uri icon


  • The etiology of early onset neonatal sepsis has changed during the past century. 1, 2 Whereas Streptococcus pyogenes was the predominant cause of neonatal sepsis during 1930 to 1940 and Escherichia coli during 1940 to 1970, group B Streptococcus emerged as a major pathogen during the late 1960s. 1S. pyogenes has been an important cause of puerperal, obstetric and neonatal morbidity and mortality from the 16th century until the beginning of the antibiotic era. 3 Since then the number of cases of neonatal sepsis caused by S. pyogenes has decreased substantially. 1 An increase in the incidence of invasive S. pyogenes diseases occurred in the 1990s including toxic shock syndrome, necrotizing fasciitis, pneumonia with empyema, meningitis and septicemia alone. 4-8 However, there were no reports showing any increase in the rate of S. pyogenes neonatal sepsis.

publication date

  • January 1, 1999