P37. 31 The antidepressant effect of subconvulsive electrical stimulation of the prefrontal cortex as compared to electroconvulsive therapy Academic Article uri icon


  • Background: Electroconvulsive therapy (ECT) is the most effective treatment for depression, with high response rate. Despite the great efficacy of this treatment it is not widely used due the associated adverse side effects (eg, short-term memory loss). Although it has been used for almost a century, the exact mechanism of its action is not clear. ECT stimulates the whole brain, however it is likely that only specific brain regions are responsible for mediation of the therapeutic effect.

publication date

  • January 1, 2006