Electrochemical interference in a catechol-modified chitosan redox cycling amplification system for clozapine detection Academic Article uri icon

abstract

  • Clozapine (CLZ) is the most effective antipsychotic drug for schizophrenia treatment [1]. It remains underutilized as frequent blood draws are required to monitor efficacy and adverse side effects. Point-of-care monitoring of drug levels would lower the burden associated with CLZ treatment for patients, enabling wider use of the medication and improving outcomes through personalized medicine. We have recently demonstrated the application of a biomaterial-based redox cycling system [2] to the detection of CLZ [3]. However, moving toward analysis in a complex biological fluid like human serum, other electroactive species may interact with the system. To evaluate potential interference with CLZ sensing, here we specifically investigate three compounds: the CLZ metabolite norclozapine, a structurally highly similar molecule present in patient blood; the model biological redox species …

publication date

  • January 1, 2013