In Obese Individuals, OSA Is Associated with Impaired Endothelial Function in Younger Subjects. Conference Paper uri icon

abstract

  • Results: 72 obese subjects were studied. 38 subjects were diagnosed with OSA (median RDI 23.3, 11.1− 122.3 events/h). There was a significant correlation between RDI and BMI, r= 0.33, p= 0.004. BMI, however, was similar between the OSA and non− OSA groups (40.2±10.4 vs. 38.4±6.0, p= 0.37). OSA subjects tended to have a higher waist: hip ratio (0.94±0.09 vs 0.85±0.09, p= 0.0007) and be older (44.1±10.2 vs 32.2±11.6 years, p< 0.001) than non− OSA subjects. The% change in FMD was decreased in OSA subjects compared to non− OSA subjects (5.7±3.8% vs 8.3±4.1%, p= 0.005). In multiple stepforward linear regression analysis inclusive of age, gender and BMI, age (p= 0.013) was a significant predictor of change in FMD. In a subgroup of subjects< 50 years old (59 subjects), however, OSA status was the only significant predictor of% change in FMD (p= 0.044), adjusted for …

publication date

  • April 1, 2009