Baseline Predictors of Immunogenicity in HVTN 204 Conference Paper uri icon

abstract

  • Summary Baseline log (Ad5 nAb titer) was negatively associated with HIV-specific CD8+ ICS responses in the univariate and forward stepwise selection models (OR 0.91; 95% CI 0.84, 0.99) for an Ad5 nAb titer increase of one tertile. However, the small sample size in this analysis may have precluded detection of small effects. Analysis of baseline demographics and reactogenicity data from larger studies may reveal response differences based on region, demographics such as BMI, host genetics, or effects seen only with certain …

publication date

  • January 1, 2013