Pharmacological study of direction selectivity in the archer fish retina Academic Article uri icon


  • Direction selective cells have been found in the retina, the first level of the visual system, in mammals and recently also in the archer fish. These cells are involved in a variety of fast neural computation processes, from the control of eye movements to the detection of prey by the archer fish. The standard model for this mechanism in mammalian retina is well understood and is based on the asymmetry of inhibitory and excitatory inputs to the retinal ganglion cells. However, it remains unclear whether the mechanism that underlies direction selectivity is similar across animal classes. This study reports a pharmacological investigation designed to elucidate the mechanism that underlies motion detection in the archer fish retina. Direction selectivity in the retina was characterized under the influence of specific channel blockers that are known to be present in the different types of neurons of …

publication date

  • January 1, 2015