A meta analysis to study the effects of body mass index on sperm DNA fragmentation index in reproductive age men Academic Article uri icon


  • Objective To assess the effects of overweight (25< BMI< 30) and obesity (BMI> 30) on sperm DNA fragmentation (SDF) in reproductive age men. Design A systematic search was conducted using MEDLINE/PubMed, SJU discover and Google Scholar to identify all relevant studies published up to 2017 (April). Participants were men from IVF/male infertility clinics and general population. The outcome measure was DNA fragmentation index (DFI). Materials and Methods The study groups were stratified and compared according to BMI categories based on WHO classification-Normal, Overweight (OW), and Obese (OB). Subgroup analysis included population type-infertile versus fertile men; and test type for DFI- Sperm chromatin structure assay (SCSA) or Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL). Results The meta-analysis included a total of 7 studies …

publication date

  • January 1, 2017