Inositol is not therapeutic in Parkinson's Disease Academic Article uri icon


  • Inositol 12 g per day was added to ongoing anti-Parkinson therapy in a controlled randomized cross-over design in nine patients. No therapeutic effect was found. Copyright © 1999 John Wiley & Sons, Ltd … KEY WORDS Ð Parkinson's Disease; inositol; second messengers; dopamine … INTRODUCTION Inositol is a simple polyol compound that has been reported to be therapeutic in depression (Levine et al., 1993), panic disorder (Benjamin et al., 1995) and obsessive compulsive disorder (OCD) (Fux et al., 1996). Doses of 12 g per day lead to a 70 per cent increase in CSF inositol (Levine et al., 1993). Inositol is a precursor of phosphatidylinositol, although its therapeutic mechanism in psychiatry has not been proven to be due to this pathway. Inositol is also therapeutic in respiratory distress syndrome of neonates (Hallman et al., 1992), and it has been suggested that this is due to effects of inositol on phospholipase D. Some dopamine (DA) receptors …

publication date

  • January 1, 1999