Gene maps linearization using genomic rearrangement distances Academic Article uri icon

abstract

  • A preliminary step to most comparative genomics studies is the annotation of chromosomes as ordered sequences of genes. Different genetic mapping techniques often give rise to different maps with unequal gene content and sets of unordered neighboring genes. Only partial orders can thus be obtained from combining such maps. However, once a total order O is known for a given genome, it can be used as a reference to order genes of a closely related species characterized by a partial order P. Our goal is to find a linearization of P that is as close as possible to O, in term of a given genomic distance. We first prove NP- completeness complexity results considering the breakpoint and the common interval distances. We then focus on the breakpoint distance and give a dynamic programming algorithm whose running time is exponential for general partial orders, but polynomial …

publication date

  • May 1, 2007