Generation of epileptiform discharges by local circuits in neocortex Academic Article uri icon


  • 12 Generation of epileptiform discharge by local circuits of neocortex BARRY W. CONNORS and YAEL AMITAI Introduction So many books have been written on epilepsy that it may seem rash to add another... (Jackson, 1874) 1 The neuronal essence of seizures is exceptionally synchronous activity. Cortical neurons performing normal tasks tend to fire with relatively low synchrony (Abeles, 1982), but during a seizure the activity of affected neurons is abruptly usurped. The kernel of this idea was suggested by John Hughlings Jackson in the nineteenth century; …

publication date

  • July 30, 1993