- Conclusion Depressivity and fatigue are among the most frequent symptoms in multiple sclerosis (MS), affecting up to 90% of patients at onset or during the course of the disease. Neither are underlying mechanisms understood, nor do convincing therapies exist. Repetitive transcranial magnetic stimulation (rTMS) has proven efficacious for treating depression. Newly developed coils, like the novel H-Coil, enable the stimulation of deeper brain regions, which are presumably involved in the pathophysiology of depression. Stimulation with the H-coil has been shown to be safe and well tolerated in healthy volunteers and efficacious in patients with major depression.