Olanzapine treatment of clozapine-induced NMS. Academic Article uri icon


  • The treatment of patients who must stop clozapine because of severe side effects is a serious clinical problem. Patients receive clozapine only after failure of typical neuroleptics and after that there are limited options if clozapine must be stopped. We recently reported two cases of clozapineinduced agranulocytosis who were treated successfully with olanzapine with no recurrence of hematological side effects (Lokshin et al., 1998). We now report a case of clozapine-induced NMS, itself a rare phenomenon (Amore et al., 1997; Tsai et al., 1995; Goates and Escobar 1992; Reddig et al., 1993; Nopoulos et al., 1990; Miller et al., 1991), treated in follow-up with olanzapine.

publication date

  • January 1, 2000