Network Meta-analysis in Mental Health Research Academic Article uri icon


  • To the Editor The network meta-analysis of various repetitive transcranial magnetic stimulation (rTMS) modalities in major depressive disorder by Brunoni et al 1 is fairly comprehensive, given the limited criteria for article selection used in this analysis. Such an approach could enhance understanding of rTMS efficacy and tolerability; however, if not implemented with great care, it can also lead to distorted conclusions.Unfortunately, this review 1 includes several methodological issues and errors. Specifically, the conclusions are compromised by the inclusion of sparse nodes with a single study (3 of 8 nodes); the grouping of different interventions into a single node (1 θ-burst stimulation node comprising 3 routes of administration); the grouping of very different sham conditions into a single node (diverse sham techniques and patients with or without concomitant antidepressants); and …

publication date

  • January 1, 2017