Different expression of P53 and P16/CDKN2 suppressor genes in melanoma cell lines and cultured melanocytes: correlation with chromosomal aberrations and tum... Academic Article uri icon

abstract

  • P53 and P16/CDKN2 are suppressor genes involved in various human malignancies, including malignant melanoma. In our present study we investigated the expression of P53 and P16 in melanoma cell lines and cultured melanocytes, in order to analyze whether the degree of their expression or deletion correlates with aggressiveness of the tumor cells. We developed five original human melanoma cell lines in our laboratory from metastases of different melanoma subtypes, as well as cultured human melanocytes. We analyzed the …

publication date

  • January 1, 1996