Abstract 4732: Association between genetic variants in the 8q24 cancer risk regions and circulating levels of androgens and sex-hormone binding globulin Academic Article uri icon

abstract

  • Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DC Multiple genome-wide association studies have identified several independent non-coding regions in chromosome 8q24 associated with risk for cancers of the prostate, breast, colon, and bladder. To explore their biological basis, we investigated the possible association between 164 single nucleotide polymorphism (SNPs) in the 8q24 risk regions, spanning 128,101,433-128,828,043 bp, and serum androgen (testosterone, androstenedione, and 3αdiol G) and sex hormone-binding globulin levels in 563 healthy, non-Hispanic, Caucasian men (55-74 years old) from a prospective cohort study, the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial. Age-adjusted linear regression using SNPs in an additive genetic model showed that three adjacent SNPs centromeric to prostate cancer risk region 2 (rs12334903, rs1456310, and [rs980171][1]) were associated with measured total testosterone (P<1.1×10−3) and calculated bioavailable testosterone (P<6.3×10−4). Suggestive associations were seen for a cluster of 9 SNPs in prostate cancer risk region 1 and androstenedione (P<0.05). These preliminary findings, although in need of confirmation in larger studies, suggest that genetic variations in the 8q24 cancer risk regions may correlate with androgen levels, which in turn may provide some clues for the strong link between 8q24 and prostate cancer risk. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4732. [1]: /lookup/external-ref?link_type=GEN&access_num=rs980171&atom=%2Fcanres%2F70%2F8_Supplement%2F4732.atom

publication date

  • January 1, 2010