508: A significant linear association exists between NT thickness and adverse perinatal outcome in euploid fetuses Academic Article uri icon


  • ADVERSE PERINATAL OUTCOME IN EUPLOID FETUSES. BOAZ SHEIZAF, EYAL SHEINER, MIRIAM FINK, RELI HERSHKOVITZ, MOSHE MAZOR, ARNON WIZNITZER, Soroka University Medical Center, Beer-Sheva, Israel OBJECTIVE: To evaluate whether there is a correlation between the nuchal translucency (NT) measurement throughout its range, independent of gestational age, and adverse pregnancy outcome, in euploid fetuses. STUDY DESIGN: A prospective observational study was conducted in which NT measurements were made in consecutive singleton euploid fetuses derived from an unselected pregnant population. Examinations were performed at 11 0/7 to 13 6/7 weeks gestation, between January 1999 and October 2006 in a University Medical Center. Pregnancies terminated before 22 weeks gestation were excluded from the analysis. RESULTS: A total of 2205 euploid fetuses were evaluated during the study period. Significant linear-by-linear association was documented between the NT measurement and perinatal mortality (P 0.001, Figure). Additionally, thicker NT was significantly associated with diabetes (either gestational or pre-gestational) (P 0.013). Selected outcomes are presented in the table.

publication date

  • January 1, 2007