732: Group B Streptococcus maternal colonization and future respiratory infections in the offspring: Results from a population based cohort of up to 18 years follow-up Academic Article uri icon


  • Objective Intrapartum antibiotic prophylaxis (IAP) is a standard of care for rectovaginal carriers of Group B Streptococcus (GBS). IAP is considered efficacious in preventing early- onset neonatal GBS disease, however the long-term health implications of carriage and IAP on offspring are unknown. Our objective was to determine whether known maternal GBS and the associated IAP impacts long term respiratory infections (RI) in offspring. Study Design A population-based cohort study was conducted between 1991-2014 comparing incidence of pediatric hospitalizations due to common RI in offspring of mothers with and without known GBS carriage. We excluded twins, deliveries of fetuses with major anatomical or chromosomal abnormalities, Rh iso-immunization, labor complications, and serious maternal infections during pregnancy. Follow-up time was calculated from birth to either …

publication date

  • January 1, 2018