Deep Transcranial Magnet Stimulation Can Improve Depression And Fatigue In Multiple Sclerosis-A Clinical Phase I/IIa Study (S33. 007) Academic Article uri icon


  • OBJECTIVE: To perform a randomized, sham-controlled phase I/IIa trial to study safety and efficacy of deep rTMS on fatigue and depression in patients with MS (NCT01106365). BACKGROUND: Fatigue and depression are frequent symptoms among multiple sclerosis (MS) patients. The underlying pathobiology is poorly understood and therapeutic strategies are limited. Repetitive transcranial magnetic stimulation (rTMS) has shown efficacy in the treatment of major depression. The recently developed H-Coil, allows stimulation of deeper brain regions, possibly involved in the pathophysiology of fatigue and depression. H-coil stimulation is safe and well tolerated in healthy volunteers, and has shown efficacy in patients with major depression. DESIGN/METHODS: 28 MS patients (42.9±9.2 years) underwent 18 sessions of deep rTMS over 6 weeks. Nine patients received true …

publication date

  • April 8, 2014