520: Activation of the alternative pathway of complement is a feature of preterm parturition but not of spontaneous labor at term Academic Article uri icon


  • Objective Fragment Bb (FBb) is a marker for activation of the alternative pathway of the complement system. High concentrations of FBb in maternal blood, as early as the first trimester, are associated with subsequent spontaneous preterm delivery< 34 weeks of gestation (Lynch, AJOG 2008). The study aim was to determine whether spontaneous preterm labor with intact membranes (PTL), intra-amniotic infection/inflammation (IAI) or labor at term are associated with alterations in circulating maternal FBb concentrations. Study Design This cross-sectional study included the following groups: 1) preterm normal pregnancy (gestational age range 20-36 6/7 weeks, n= 63); 2) women at term not in labor (n= 70); 3) women at term in spontaneous labor (n= 59); 4) patients with an episode of PTL who delivered at term (n= 62); 5) PTL without IAI who delivered preterm (n= 30); and 6) …

publication date

  • December 1, 2009