- Objective Exploration of the possibility that local injury of the endometrium increases the incidence of implantation. Design Prospective study. Setting Clinical IVF unit. Patient(s) A group of 134 patients, defined as good responders to hormonal stimulation, who failed to conceive during one or more cycles of IVF and embryo transfer (ET). Intervention(s) The IVF treatment and ET were preceded by repeated endometrial biopsies, in a randomly selected 45 of a total of 134 patients. Main outcome measure(s) Outcome of IVF-ET treatments. Result(s) Transfer of a similar number of embryos (3.4 ± 1.0 and 3.1 ± 0.9 in the experimental and control patients, respectively) resulted in rates of implantation (27.7% vs. 14.2%, P = .00011), clinical pregnancy (66.7% vs. 30.3%, P = .00009), and live births per ET (48.9% vs. 22.5%, P = .016) that were more than twofold higher in the experimental group as compared to controls. Conclusion(s) These results suggest that IVF treatment that is preceded by endometrial biopsy doubles the chance for a take-home baby.