Cerebrospinal cytokine levels in patients with acute depression Academic Article uri icon


  • Dr. Joseph Levine Western Psychiatric Institute and Clinic 3811 O'Hara Street Pittsburgh, PA 15213-2593 (USA) Tel. +1 412 624 0275, Fax +1 412 624 0493 … ABC Fax + 41 61 306 12 34 E-Mail karger@karger.ch www.karger.com … © 1999 S. Karger AG, Basel 0302–282X/99/0404–0171$17.50/0 Accessible online at: www.karger.com/journals/nps … Key Words Depression W Psychoimmunology W Cytokines W Interleukin-1 W Interleukin-6 … Abstract There is increasing evidence for an association between the alteration of cytokine concentrations in blood and the pathophysiology of depressive disorders. Studies in hu- mans have not investigated CSF cytokine concentrations and their relationship to depressive disorders. This study reports on the association of the CSF concentration of proinflammatory cytokines, IL-1ß, IL-6 and TNF·, and major depressive disorders. CSF samples were obtained from 13 hospitalized …

publication date

  • January 1, 1999