814: First trimester pregnancy loss and the expression of natural cytotoxicity receptors NKp46 and NKp30 in maternal blood and placental tissue Academic Article uri icon


  • RESULTS: Ten studies were included for analysis (2,211 subjects). QUADAS scores ranged from 8-13. For delivery within 48 hours employing 15 mm as the selected cut off, the overall pooled estimates for sensitivity and specificity were 0.77 (95% confidence interval [CI] 0.54- 0.90) and 0.88 (95% CI 0.84-0.91), respectively and a DOR of 24 (95% CI 9-65). Positive and negative likelihood ratios based on the selected 15 mm cut off were 6.4 (95% CI 4.7-8.7) and 0.26 (95% CI 0.12-0.58) respectively. The area under the curve was 0.90 (0.88-0.93). Based on a pre-test probability of 10% for delivery within 48 hours of testing, post-test probabilities (positive and negative) were 42% and 3% respectively. CONCLUSION: In women with signs and symptoms of preterm labor, TVS cervical length measurement has moderate accuracy for predicting delivery within 48 hours of testing.

publication date

  • January 1, 2014