Role of GSK3β in behavioral abnormalities induced by serotonin deficiency Academic Article uri icon


  • We were interested to read the article by Beaulieu et al.(1), suggesting that GSK3ß haploinsufficiency counteracts depressive-like behavior in mice expressing a functional TPH2 mutant with a marked decrease in serotonin production. In the figures of the current article, it is clear that GSK3ß haploinsufficiency had no antidepressant effect in the tail suspension test in animals without the TPH2 mutant enzyme. However, Beaulieu et al. fail to mention the paper by O'Brien et al.(2), who reported that GSK3ß haploinsufficiency alone …

publication date

  • January 1, 2008