Lighting-up the dynamics of telomerization and DNA replication by CdSe- ZnS quantum dots Academic Article uri icon

abstract

  • Hybrid systems consisting of semiconductor quantum dots (QDs) coupled to biomaterials find growing interest in the developing research area of nanobiotechnology. 1,2 Photochemically induced fluorescence resonance energy transfer (FRET) between molecular fluorophores 3-5 or the quenching of excited chromophores by metal nanoparticles 6 was reported to probe DNA hybridization processes and, specifically, the formation and dissociation of hairpin structures. The replication of DNA on bulk surfaces was recently applied to the amplified bioelectronic detection of DNA, 7 and the incorporation of redox-active units into the replicated DNA has enabled the electrochemical probing of the dynamics of replication. 8 The unique photophysical properties of semiconductor quantum dots establish the possibility of applying semiconductor nanoparticles as efficient fluorescence labels 9 or as photoelectrochemical probes. 10 Here, we report …

publication date

  • January 1, 2003