Specific inhibition by the synthetic copolymer COP-1 of human T cell lines specific to myelin basic protein Academic Article uri icon

abstract

  • M. Saivetti, C. Buttinelli, P. FiorL L. Toma, C. Pozzilli aid C. Fiesehi. Dept. of Neurological Sciences University of Rome," La Sapienza" Recently, the study of the T cell immunodominant regions of mye! in basic protein (MBP) in multiple sclerosis (MS) took dvantage of a new method which allows the generation of antigen s2~ ecific T cell lines (TCL) with high efficiency (M. Pette et al. Neurology 1990; 40: 1770). By using this approach, we established 148 MBP specific TCL from the peripheral blood of 9 patients with definite MS (n= 69) and 11 healthy donors (n= 89). So far, 19 MBP specific TCL from 6 patients and 23 MBP specific TCL from 7 healthy individuals have been tested for their proliferative response to a panel of four synthetic peptidos (kindly provided by Prof. H. Wekerle) representing MBP residues 7-26 (3 specific TCL from patients and 5 from controls), 80-99 …

publication date

  • January 1, 1991