Extrinsic factors inducing oxidative stress (OS) in male and female reproductive systems Academic Article uri icon


  • Reactive oxygen species (ROS) are free radical and non-free radical oxidizing agents that play a normal physiological role in the body at low physiological amount [1]. Biological reactions and mitochondrial processes generate regular amounts of ROS. In the female reproductive system, ROS plays an essential role in signal transduction pathways and metabolic pathways in processes such as follicular development, oocyte maturation, ovulation, implantation, steroidogenesis, and maintenance of pregnancy. In the male reproductive system, ROS are critical in spermatozoa capacitation, hyperactivation, acrosome reaction and sperm-oocyte fusion [2, 3].

publication date

  • January 1, 2017