Circulating cell-free DNA levels measured by a novel simple fluorescent assay are predictive for outcome of severe sepsis Academic Article uri icon


  • Methods Seventy-six patients diagnosed with severe sepsis hospitalized in the ICU were enrolled in the study. Serum CFD levels were measured upon admission and after 72 hours using the SYBR-Gold rapid direct fluorescent assay [2]. Primary outcome was 28-day mortality. Logistic regression analysis of CFD quintiles adjusted for baseline comorbidities and severity of the disease was utilized. Results Out of those diagnosed with severe sepsis, 28 (36.8%) have died either during hospitalization or within 28 days of admission to the …

publication date

  • January 1, 2012