Stress, adrenaline and CRH provide neuroprotection in traumatic brain injury by enhancing the brain-to-blood glutamate driving force: 7AP5-7 Academic Article uri icon

abstract

  • Materials and Methods: Sprague Dawley rats were anesthetized and divided into treatment groups: sham, control, Adrenaline, Noreadrenaline, Corticotropin releasing hormone, Hydrocorticosterone. TBI was inflicted by a free falling rod. Treatment regimens were infused intravenously, and G levels determined 30 min after treatment. Comparisons between different groups was assessed using ANOVA with Bonferroni post hoc testing. Results and Discussion: TBI was shown to reduce blood glutamate significantly (TBI 190±5 μM/l vs. Sham 162±4 μM/l, p< 0.01). TBI increased corticosterone levels 2.6 fold, confirming the rats were in stress. CRF exerted a transient effect, decreasing blood Glu level at 30 min to 40% of its basal level. Hydrocortisone was observed to cause no significant changes of the blood G. Administration of adrenaline produced a fast and sustained reduction of blood Glu …

publication date

  • June 12, 2010