Maternal hypoxia during pregnancy delays the development of motor refl exes in newborn mice Academic Article uri icon


  • Maternal insults during pregnancy, including hypoxia, seizures, and infection, are known to be major causes of fetal brain damage. The association between hypoxia and fetal brain damage is well described and proven [1] . Hy- poxia can produce temporary brain dysfunction or per- manent brain injury, depending on the duration, inten- sity of oxygen deprivation and age of the fetus. Accumulating evidence in the last decade suggests that glutamate-mediated excitotoxicity may play an impor- tant role in neuronal injury [2] . The hypoxia/ischemia cascade leads to neuronal cell death through overstimula- tion of the excitatory amino acid receptors [3, 4] , cellular calcium influx, and formation of free radicals and nitric oxide. The mechanisms or pathophysiology of hypoxia- induced fetal neurotoxicity are complex and not fully un- derstood. The physiological characteristics of the gluta- mate N-methyl- D -aspartate receptor (NMDAR) changed …

publication date

  • January 1, 2004