- Abstract We report on a 3-generation family with 4 members affected with congenital low anorectal malformations. The vertical segregation of the anomalies and the occurrence of affected males and females support autosomal-dominant inheritance, which was suggested previously for this type of congenital anomaly. Am. J. Med. Genet. 71:280–282, 1997. © 1997 Wiley-Liss, Inc.