Long-term effects of topiramate on bipolar mood instability, weight change and glycemic control: a case-series Academic Article uri icon


  • Topiramate is an antiepileptic agent, which is being investigated as a mood-stabilizer. Three obese individuals with DSM-IV bipolar I disorder and type II diabetes mellitus received topiramate treatment in combination with antipsychotics and valproate or carbamazepine. In addition to improved mood stability, these individuals lost between 16 to 20.5% of their pre- topiramate body weight and also achieved significant glycemic control.

publication date

  • January 1, 2001