Trophoblast, galectin-1 and pre-eclampsia Academic Article uri icon

abstract

  • Objective Galectin-1 (Gal-1), a major anti-inflammatory placental protein expressed by immune cells that can bias the character of inflammatory responses toward the Th2 type. Important features of Gal-1 are: 1) expression in immune privileged sites; and 2) it has been used for prevention of graft vs host disease in transplantation. Normal pregnancy represents an ideal graft (more precisely semi-allograft) and is associated with microchimerism (required for the success of transplantation). We propose that an abnormal immune response in some pregnancy complications may lead to expression changes of Gal-1. To test this, we studied placental expression of Gal-1 and determined maternal serum concentrations in normal pregnancy (NP), pre-eclampsia (PE), and small-for-gestational age (SGA). Study design This cross-sectional study included the following groups matched for …

publication date

  • December 1, 2006