Expression of raf oncogenes activates the PEA1 transcription factor motif. Academic Article uri icon

abstract

  • ABSTRACT PEA1 (AP1) motif transcription enhancer activity was stimulated by v-raf and more efficiently by activated c-raf-1 or A-raf than by their normal counterparts, in agreement with a role for PEA1 in transformation by raf. Mutations in the ATP-binding site of v-raf prevented activation, suggesting that phosphorylation is somehow required.

publication date

  • January 1, 1989