A Synthetic and Predictive Approach to Unsymmetrical Biphenols by Iron-Catalyzed Chelated Radical-Anion Oxidative Coupling. Academic Article uri icon

abstract

  • An iron-catalyzed oxidative unsymmetrical biphenol coupling in 1, 1, 1, 3, 3, 3- hexafluoropropan-2-ol that proceeds via a chelated radical–anion coupling mechanism was developed. Based on mechanistic studies, electrochemical methods, and density functional theory calculations, we suggest a general model that enables prediction of the feasibility of cross-coupling for a given pair of phenols.

publication date

  • August 28, 2015