Deep repetitive transcranial magnetic stimulation (rTMS) of dorsomedial prefrontal cortex improves social relating in autism spectrum disorder Academic Article uri icon


  • Autism spectrum disorder (ASD) is characterised by impairments in social relating. A dominant model of ASD suggests that these social relating impairments are a result of a reduced capacity for theory of mind or mentalising, which itself has been linked to a neural network that includes dorsomedial prefrontal cortex (dmPFC). As individuals with ASD show reduced activity within dmPFC, we investigated whether modulation of this region with repetitive transcranial magnetic stimulation (rTMS) would improve social relating and mentalising in adults diagnosed with ASD. In a double-blind, sham-controlled clinical trial, adults with ASD underwent ten 15-minute sessions of high-frequency (5 Hz) deep rTMS to dmPFC over a two week period. Assessments of social relating and mentalising were conducted before the first deep rTMS treatment, immediately after the last deep rTMS …

publication date

  • January 1, 2015